Acute & maintenance treatment of schizophrenia in adults. Schizoaffective disorder in adults as monotherapy & adjunct to mood stabilizers or antidepressants.
Schizophrenia Initially 150 mg on day 1 & 100 mg 1 wk later by deep IM inj, followed by mthly maintenance dose: 75 mg. Dose may be adjusted w/in range: 25-150 mg. Schizoaffective disorder Initially 150 mg on day 1 & 100 mg 1 wk later by deep IM inj. Mthly maintenance dose range: 50-150 mg. Mild renal impairment (CrCl ≥50 to <80 mL/min) Initially 100 mg on day 1 & 75 mg 1 wk later by deep IM inj, followed by mthly dose: 50 mg. Dose may be adjusted w/in range: 25-100 mg.
Discontinue use if hypersensitivity reactions, NMS or tardive dyskinesia/extrapyramidal symptoms occur. Not to be inj in divided doses, intravascularly or SC. Avoid inadvertent inj into blood vessel. History of cardiac arrhythmias, congenital long QT syndrome; hyperglycemia & DM; wt gain; known CV or cerebrovascular disease or conditions predisposing to hypotension; seizures or conditions lowering seizure threshold; clinically significant low WBC or drug-induced leukopenia/neutropenia; risk factors for VTE; Parkinson's disease & dementia w/ Lewy bodies; priapism. Intraoperative floppy iris syndrome. Antiemetic effect. Conditions contributing to core body temp elevation or dehydration. Concomitant use w/ risperidone or PO paliperidone; psychostimulants eg, mehthylphenidate; drugs prolonging QT interval. May affect ability to drive & use machines. Not recommended in moderate or severe renal impairment. Hepatic impairment. Pregnancy. Not to be used during lactation. Ped <18 yr. Elderly w/ dementia.
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